Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics.Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children.Represcription of penicillin after allergic-like events.
Thus, our data indicate that cephalosporins can be considered for patients with penicillin allergy. Cross-reactivity is not an adequate explanation for this increased risk, and the risk of anaphylaxis is very low. CONCLUSION: Patients with allergic-like events after penicillin had a markedly increased risk of events after either subsequent cephalosporins or sulfonamide antibiotics.
The unadjusted risk ratio for sulfonamide antibiotic, rather than cephalosporin after penicillin allergic-like events was 7.2 (confidence interval 3.8-13.5). The absolute risk of anaphylaxis after a cephalosporin was less than 0.001%. Among patients receiving a penicillin followed by a cephalosporin, the unadjusted risk ratio of an allergic-like event for those who had a prior event, compared with those who had no such prior event, narrowly defined, was 10.1 (confidence interval 7.4-13.8). RESULTS: A total of 3,375,162 patients received a penicillin 506,679 (15%) received a subsequent cephalosporin. Comparison was made with a population of patients receiving a prescription for a penicillin followed by a prescription for a sulfonamide antibiotic. Allergic events were defined by 2 sets of codes: 1 more restrictive, 1 more inclusive.
We selected all patients receiving a prescription for penicillin followed by a prescription for a cephalosporin and identified allergic-like events within 30 days after each prescription. METHODS: We conducted a retrospective cohort study using the United Kingdom General Practice Research Database. N2 - BACKGROUND: We sought to determine the risk of an allergic reaction to a cephalosporin exposure in those with prior penicillin reactions. T1 - Is there cross-reactivity between penicillins and cephalosporins?
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